Multi-Domain Touchscreen-Based Cognitive Assessment of C57BL/6J Female Mice Shows Whole-Body Exposure to 56Fe Particle Space Radiation in Maturity Improves Discrimination Learning Yet Impairs Stimulus-Response Rule-Based Habit Learning

Multi-Domain Touchscreen-Based Cognitive Assessment of C57BL/6J Female Mice Shows Whole-Body Exposure to 56Fe Particle Space Radiation in Maturity Improves Discrimination Learning Yet Impairs Stimulus-Response Rule-Based Habit Learning

Astronauts during interplanetary missions will be exposed to galactic cosmic radiation, including charged particles like 56Fe. Most preclinical studies with mature, “astronaut-aged” rodents suggest space radiation diminishes performance in classical hippocampal- and prefrontal cortex-dependent tasks...

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Bibliographic Details
Main Authors: DeSalle, M.J (Author), Eisch, A.J (Author), Gibson, A.D (Author), Kiffer, F.C (Author), Kumar, P.L (Author), Reynolds, R.P (Author), Rong, Y. (Author), Soler, I. (Author), Stowe, A.M (Author), Tran, F.H (Author), Whoolery, C.W (Author), Yun, S. (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2021
Subjects:
adult
animal experiment
anxiety
appetitive behavior
Article
behavioral pattern separation
C57BL 6 mouse
cognition assessment
controlled study
dentate gyrus
depression
discrimination learning
female
galactic cosmic radiation
hippocampus
HZE particle fractionation
iron
latent period
learning
male
maturity
mental task
mouse
nonhuman
operant behavioral test
particle radiation
prefrontal cortex
psychological extinction
radiation exposure
reward
rodent touchscreen
rule based habit learning
social interaction
stimulus response
striatum
visuomotor coordination
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