Effects of Chronic Social Defeat Stress on Behavior and Dopamine Receptors in Adolescent Mice With 6-Hydroxydopamine Lesions of the Medial Prefrontal Cortex

Effects of Chronic Social Defeat Stress on Behavior and Dopamine Receptors in Adolescent Mice With 6-Hydroxydopamine Lesions of the Medial Prefrontal Cortex

Background: Social stress factors in schizophrenia have long-term effects, but will only induce symptoms in a portion of individuals, even if exposed to identical stress. Methods: In the current experiment, we examined mice with 6-hydroxydopamine (6-OHDA)-induced medial prefrontal cortical (mPFC) in...

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Bibliographic Details
Main Authors: Gao, X. (Author), Huang, G.-B (Author), Zhao, T. (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2021
Subjects:
adolescent
amygdala
animal experiment
animal model
anxiety
Article
behavior
chronic social defeat
cognitive defect
controlled study
depression
dopamine 1 receptor
dopamine 2 receptor
dopamine beta monooxygenase
dopamine receptor
forced swim test
hippocampus
light dark cycle
locomotion
medial prefrontal cortex
mouse
nonhuman
novel object recognition test
oxidopamine
physiological stress
prefrontal cortex
protein expression level
schizophrenia
social avoidance
social defeat stress
social interaction
stress-susceptible
tyrosine 3 monooxygenase
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