A Novel Assay Allowing Drug Self-Administration, Extinction, and Reinstatement Testing in Head-Restrained Mice

A Novel Assay Allowing Drug Self-Administration, Extinction, and Reinstatement Testing in Head-Restrained Mice

Multiphoton microscopy is one of several new technologies providing unprecedented insight into the activity dynamics and function of neural circuits. Unfortunately, some of these technologies require experimentation in head-restrained animals, limiting the behavioral repertoire that can be integrate...

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Bibliographic Details
Main Authors: Bobadilla, A.-C (Author), Bowen, C.W (Author), Doncheck, E.M (Author), Grant, R.I (Author), Green, L.M (Author), Kalivas, P.W (Author), Otis, J.M (Author), Romanova, E.V (Author), Siegler, P.N (Author), Trujillo-Pisanty, I. (Author), Vollmer, K.M (Author), Winston, K.T (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2021
Subjects:
addiction
animal experiment
animal model
Article
association
behavior
brain function
calcium imaging
cocaine
controlled study
diamorphine
drug dependence
drug self administration
drug use
ensembles
female
longitudinal tracking of individual cells
male
mouse
multiphoton microscopy
nerve cell plasticity
nonhuman
physical restraint
physiological stress
psychological extinction
reinstatement
relapse
reward
sex difference
sucrose
two-photon (2P)
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