Changes in Brain Matrix Glycan Sulfation Associate With Reactive Gliosis and Motor Coordination in Mice With Head Trauma

Changes in Brain Matrix Glycan Sulfation Associate With Reactive Gliosis and Motor Coordination in Mice With Head Trauma

Perineuronal nets (PNNs) are extracellular matrix (ECM) structures that enmesh and regulate neurocircuits involved in motor and sensory function. Maladaptive changes to the composition and/or abundance of PNNs have been implicated in preclinical models of neuroinflammation and neurocircuit destabili...

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Bibliographic Details
Main Authors: Alonge, K.M (Author), Banks, W.A (Author), Cook, D.G (Author), Herbert, M.J (Author), Logsdon, A.F (Author), Yagi, M. (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2021
Subjects:
adult
agglutinin
animal experiment
animal model
animal tissue
Article
C57BL 6 mouse
chondroitin sulfate (CS)
correlation analysis
dermatan sulfate
extracellular matrix
gene expression
gliosis
glycosaminoglycans (GAGs)
head injury
histopathology
liquid chromatography-mass spectrometry
maladjustment
male
motor coordination
motor cortex
motor dysfunction
mouse
nerve cell network
nervous system inflammation
nonhuman
perineuronal net
perineuronal nets (PNNs)
protein localization
proteochondroitin sulfate
sensorimotor function
somatosensory cortex
sulfation
sulfotransferase
thalamus
tissue repair
traumatic brain injury
ubiquitin carboxyl terminal hydrolase L1
ubiquitin thiolesterase
unclassified drug
upregulation
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