An Advanced Transcriptional Response to Corticosterone After Single Prolonged Stress in Male Rats

An Advanced Transcriptional Response to Corticosterone After Single Prolonged Stress in Male Rats

Stress-related neuropsychiatric disorders are often accompanied by dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis. In patients suffering from post-traumatic stress disorder (PTSD), increased sensitivity of glucocorticoid negative feedback has regularly been observed. The single prolong...

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Bibliographic Details
Main Authors: Chen, X. (Author), Ding, J. (Author), Han, F. (Author), Meijer, O.C (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2021
Subjects:
adult
amygdala
animal experiment
animal model
animal tissue
Article
brain region
controlled study
corticosterone
dorsal hippocampus
drug blood level
drug response
FKBP5
gene expression
glucocorticoid receptor
GR sensitivity
hippocampus
male
negative feedback
nonhuman
physiological stress
posttraumatic stress disorder
protein expression
rat
receptor sensitivity
signal transduction
single prolonged stress
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