Characterizing Sex Differences in Depressive-Like Behavior and Glial Brain Cell Changes Following Peripheral Nerve Injury in Mice

Characterizing Sex Differences in Depressive-Like Behavior and Glial Brain Cell Changes Following Peripheral Nerve Injury in Mice

Chronic pain and depression are intimately linked; the combination of the two leads to higher health care costs, lower quality of life, and worse treatment outcomes with both conditions exhibiting higher prevalence among women. In the current study, we examined the development of depressive-like beh...

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Bibliographic Details
Main Authors: Cho, C. (Author), Lidhar, N.K (Author), Martin, L.J (Author), Michailidis, V. (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2021
Subjects:
affect
anhedonia
animal cell
anterior cingulate
Article
astrocyte
astrocytes
brain region
cell activation
cell density
chronic pain
cohort analysis
comorbidity
controlled study
depression
depressive-like
disease course
dorsal anterior cingulate cortex
experimental behavioral test
female
forced swim test
forced swim test and tail suspension test
glia cell
glial fibrillary acidic protein
immobility
immunohistochemistry
macroglia
male
microglia
mouse
neuropathic pain
nonhuman
nucleus accumbens
open field test
pathogenesis
peripheral nerve injury
sex difference
spared nerve injury
staining
sucrose preference test
tail suspension test
treatment response
von Frey test
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