Self-Administration of Entactogen Psychostimulants Dysregulates Gamma-Aminobutyric Acid (GABA) and Kappa Opioid Receptor Signaling in the Central Nucleus of the Amygdala of Female Wistar Rats

Self-Administration of Entactogen Psychostimulants Dysregulates Gamma-Aminobutyric Acid (GABA) and Kappa Opioid Receptor Signaling in the Central Nucleus of the Amygdala of Female Wistar Rats

Male rats escalate intravenous self-administration of entactogen psychostimulants, 3,4-methylenedioxymethcathinone (methylone) and 3,4-methylenedioxymethamphetamine (MDMA) under extended access conditions, as with typical psychostimulants. Here, we investigated whether female rats escalate self-admi...

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Bibliographic Details
Main Authors: Grant, Y. (Author), Khom, S. (Author), Nguyen, J.D (Author), Roberto, M. (Author), Taffe, M.A (Author), Vandewater, S.A (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2021
Subjects:
4 aminobutyric acid A receptor
4 aminobutyric acid release
animal behavior
animal experiment
Article
brain electrophysiology
brain slice
central amygdala
central nucleus (amygdala)
chemical structure
controlled study
drug self administration
dynorphin
electrophysiology
entactogen
female
GABAergic transmission
inhibitory synaptic transmission
intravenous self-administration
kappa opiate receptor
MDMA
methylone
nonhuman
pentylone
postsynaptic inhibition
psychostimulant agent
rat
unclassified drug
whole cell patch clamp
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