NUDT15 Genetic Variants in Chinese Han, Uighur, Kirghiz, and Dai Nationalities

Background: Thiopurines are widely used as anti-cancer and immunosuppressant agents, but have a narrow therapeutic index owing to frequent toxicity and life-threatening bone marrow suppression. The nudix hydrolase 15 (NUDT15) genetic polymorphism is strongly associated with the tolerance and myelosu...

Full description

Bibliographic Details
Main Authors: Amat, G. (Author), Chen, C. (Author), Chen, R. (Author), Hu, W. (Author), Shen, S. (Author), Tang, Y. (Author), Tian, X. (Author), Xie, Y. (Author), Zhang, F. (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2022
Subjects:
Dai
Online Access:View Fulltext in Publisher