Mechanisms underlying the anti-inflammatory effects of Clinacanthus nutans lindau extracts: Inhibition of cytokine production and toll-like receptor-4 activation

Mechanisms underlying the anti-inflammatory effects of Clinacanthus nutans lindau extracts: Inhibition of cytokine production and toll-like receptor-4 activation

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Clinacanthus nutans has had a long history of use in folk medicine in Malaysia and Southeast Asia; mostly in the relief of inflammatory conditions. In this study, we investigated the effects of different extracts of C. nutans upon lipopolysaccharide (LPS) induced inflammation in order to identify it...

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Bibliographic Details
Main Authors: Chin, S.Y (Author), Ismail, N.H (Author), Kho, M.T (Author), Lim, E.S.H (Author), Mai, C.W (Author), Shaari, K. (Author), Yap, K.S.I (Author), Yusoff, K. (Author)
Format: Article
Language:English
Published: Frontiers Media S.A. 2016
Subjects:
antiinflammatory activity
antiinflammatory agent
Anti-inflammatory agents
Article
cell line RAW 264.7
Clinacanthus nutans
Clinacanthus nutans extract
Clinacanthus nutans Toll-like receptor 4
concentration response
controlled study
cytokine production
cytotoxicity test
drug determination
flavonoid
gamma interferon
interferon regulatory factor 3
interleukin 12p40
interleukin 17
interleukin 1beta
interleukin 6
macrophage
Macrophages
medicinal plant
mitogen activated protein kinase
phenol
plant extract
plant leaf
plant stem
stress activated protein kinase
synaptophysin
synaptotagmin I
toll like receptor 4
Total flavonoid content
tumor necrosis factor alpha
unclassified drug
Western blotting
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