In Vitro Hepatic Metabolism of Curcumin Diethyl Disuccinate by Liver S9 from Different Animal Species

In Vitro Hepatic Metabolism of Curcumin Diethyl Disuccinate by Liver S9 from Different Animal Species

Liver S9 (LS9) is a nearly complete collection of all hepatic drug-metabolizing enzymes. It is a low-cost model for predicting drug metabolic activity. This study aimed to identify the suitability of using LS9 of different animal sources in drug metabolism profiling with respect to the possible tran...

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Bibliographic Details
Main Authors: Jithavech, P. (Author), Qiu, G. (Author), Ratnatilaka Na Bhuket, P. (Author), Rojsitthisak, P. (Author), Supasena, W. (Author), Wong, T.W (Author), Wu, J. (Author), Ye, S. (Author)
Format: Article
Language:English
Published: Frontiers Media S.A., 2020
Subjects:
anthropometric parameters
antineoplastic agent
Article
carboxylesterase
cholinesterase
clinical study
curcumin
curcumin diethyl disuccinate
dimethylcurcumin
dog
drug clearance
drug degradation
drug half life
drug metabolism
drug structure
Haplorhini
human
In vitro metabolism
in vitro study
in vivo study
liver enzyme
liver metabolism
liver S9
liver to body weight ratio
monoethylsuccinyl curcumin
nonhuman
outcome assessment
species comparison
ultra performance liquid chromatography
unclassified drug
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