Protective effect of palm oil-derived tocotrienol-rich fraction against retinal neurodegenerative changes in rats with streptozotocin-induced diabetic retinopathy

Protective effect of palm oil-derived tocotrienol-rich fraction against retinal neurodegenerative changes in rats with streptozotocin-induced diabetic retinopathy

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Oxidative stress plays an important role in retinal neurodegeneration and angiogenesis associated with diabetes. In this study, we investigated the effect of the tocotrienol-rich fraction (TRF), a potent antioxidant, against diabetes-induced changes in retinal layer thickness (RLT), retinal cell cou...

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Bibliographic Details
Main Authors: Agarwal, R. (Author), Ismail, N.M (Author), Nasir, N.A.A (Author), Sadikan, M.Z (Author)
Format: Article
Language:English
Published: MDPI AG, 2020
Subjects:
alpha tocotrienol
Angiogenesis
animal
animal cell
animal experiment
animal model
animal tissue
Animals
apoptosis
Apoptosis
Article
body weight
Body Weight
body weight gain
cell count
cell protection
chemistry
controlled study
Cytoprotection
diabetic retinopathy
Diabetic retinopathy
Diabetic Retinopathy
drug effect
gene expression regulation
Gene Expression Regulation
glucose
glucose blood level
male
Male
metabolism
nonhuman
palm oil
Palm Oil
pathology
protein expression
rat
rat model
Rats
Rats, Sprague-Dawley
retina
Retina
retina cell
retina degeneration
retinal ganglion cell layer
retinal nerve fiber layer thickness
retinal neurodegeneration
Sprague Dawley rat
streptozocin
Streptozocin
Streptozotocin
Tocotrienol-rich fraction
Tocotrienols
TUNEL assay
Vascular Endothelial Growth Factor A
vasculotropin
vasculotropin A
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