Monoamine oxidase inhibition by major tanshinones from salvia miltiorrhiza and selective muscarinic acetylcholine m4 receptor antagonism by tanshinone i

Monoamine oxidase inhibition by major tanshinones from salvia miltiorrhiza and selective muscarinic acetylcholine m4 receptor antagonism by tanshinone i

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Monoamine oxidases (MAOs) and muscarinic acetylcholine receptors (mAChRs) are considered important therapeutic targets for Parkinson’s disease (PD). Lipophilic tanshinones are major phytoconstituents in the dried roots of Salvia miltiorrhiza that have demonstrated neuroprotective effects against dop...

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Bibliographic Details
Main Authors: Choi, J.S (Author), Fauzi, F.M (Author), Jung, H.A (Author), Park, S.E (Author), Paudel, P. (Author), Prajapati, R. (Author), Seong, S.H (Author)
Format: Article
Language:English
Published: MDPI 2021
Series:Biomolecules
Subjects:
Abietanes
acetylcholine
amine oxidase (flavin containing)
amine oxidase (flavin containing) isoenzyme A
amine oxidase (flavin containing) isoenzyme B
angiotensin 2 receptor
animal
Animals
Article
beta 1 adrenergic receptor
binding affinity
blood brain barrier
bradykinin B1 receptor
Caco-2 cell line
calcium cell level
cell membrane permeability
central nervous system
chemistry
CHO cell line
CHO Cells
cholecystokinin B receptor
computer model
controlled study
Cricetulus
cryptotanshinone
drug likeness
drug solubility
endothelin 1
enzyme inhibition
enzyme inhibition assay
enzyme kinetics
G protein coupled receptor
gastrointestinal absorption
genetics
histamine H1 receptor
human
human cell
Humans
IC50
isobutylmethylxanthine
lead likeness
M4 receptor antagonist
metabolism
mitogen activated protein kinase 14
molecular docking
Molecular docking
molecular dynamics
Monoamine Oxidase
monoamine oxidase A, human
Monoamine oxidase inhibition
monoamine oxidase inhibitor
Monoamine Oxidase Inhibitors
muscarinic M1 receptor
muscarinic M2 receptor
muscarinic M3 receptor
muscarinic M4 receptor
muscarinic M5 receptor
Parkinson’s disease
pharmacokinetic parameters
pharmacology
phenanthrene derivative
Phenanthrenes
prostaglandin G
prostaglandin synthase
protein serine threonine kinase
protein structure
RBL-1 cell line
Receptor, Muscarinic M4
Salvia miltiorrhiza
scatter factor receptor
sensitivity and specificity
sequence alignment
serotonin 2A receptor
somatostatin receptor 2
stress activated protein kinase 1
tanshinone
tanshinone I
Tanshinone I
tanshinone IIA
toxicity
vasculotropin receptor 1
vasopressin V1b receptor
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