Arsenic Activates the ER Stress-Associated Unfolded Protein Response via the Activating Transcription Factor 6 in Human Bronchial Epithelial Cells

Arsenic Activates the ER Stress-Associated Unfolded Protein Response via the Activating Transcription Factor 6 in Human Bronchial Epithelial Cells

Arsenic is a well-known human carcinogen associated with a number of cancers, including lung cancers. We have previously shown that long-term exposure to an environmentally relevant concentration of inorganic arsenic (As3+) leads to the malignant transformation of the BEAS2B cells, and some of the t...

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Bibliographic Details
Main Authors: Almutairy, B. (Author), Bi, Z. (Author), Chen, F. (Author), Fu, Y. (Author), Hüttemann, M. (Author), Qiu, Y. (Author), Thakur, C. (Author), Wadgaonkar, P. (Author), Wan, J. (Author), Zhang, Q. (Author), Zhang, W. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
arsenic
ATF6
ER stress
metabolism
Nrf2
UPR
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