KHK, PNPLA3 and PPAR as Novel Targets for the Anti-Steatotic Action of Bempedoic Acid

KHK, PNPLA3 and PPAR as Novel Targets for the Anti-Steatotic Action of Bempedoic Acid

Bempedoic acid (BemA) is an ATP-citrate lyase (ACLY) inhibitor used to treat hypercholesterolemia. We studied the anti-steatotic effect of BemA, and the mechanisms involved, in a model of fatty liver in female rats obtained through the administration of a high-fat diet supplemented with liquid fruct...

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Bibliographic Details
Main Authors: Alegret, M. (Author), Bentanachs, R. (Author), Laguna, J.C (Author), Lázaro, I. (Author), Rodríguez-Morató, J. (Author), Roglans, N. (Author), Sala-Vila, A. (Author), Sánchez, R.M (Author), Velázquez, A.M (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
bempedoic acid
fructokinase
fructose
NAFLD
triglycerides
β-oxidation
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