Ubiquitin-Specific Protease 6 n-Terminal-like Protein (USP6NL) and the Epidermal Growth Factor Receptor (EGFR) Signaling Axis Regulates Ubiquitin-Mediated DNA Repair and Temozolomide-Resistance in Glioblastoma

Ubiquitin-Specific Protease 6 n-Terminal-like Protein (USP6NL) and the Epidermal Growth Factor Receptor (EGFR) Signaling Axis Regulates Ubiquitin-Mediated DNA Repair and Temozolomide-Resistance in Glioblastoma

Glioblastoma multiforme (GBM) is the most malignant glioma, with a 30–60% epidermal growth factor receptor (EGFR) mutation. This mutation is associated with unrestricted cell growth and increases the possibility of cancer invasion. Patients with EGFR-mutated GBM often develop resistance to the avail...

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Bibliographic Details
Main Authors: Chuang, H.-Y (Author), Fong, I.-H (Author), Huang, H.-C (Author), Lin, C.-M (Author), Setiawan, S.A (Author), Su, I.-C (Author), Su, Y.-K (Author), Yadav, V.K (Author), Yeh, C.-T (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
DNA repair
drug resistance
glioblastoma
ubiquitin-proteasome system
USP6NL
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