Cas14a1-Mediated Nucleic Acid Diagnostics for Spinal Muscular Atrophy

Cas14a1-Mediated Nucleic Acid Diagnostics for Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is the main genetic cause of infant death. In >95% of the patients with SMA, the disease is caused by a single hotspot pathogenic mutation: homozygous deletion of exon 7 of the survival motor neuron 1 gene (SMN1). Recently, clustered regularly interspaced short palin...

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Bibliographic Details
Main Authors: Chen, M. (Author), Feng, M. (Author), Hu, Z. (Author), Li, Z. (Author), Liang, D. (Author), Wu, L. (Author), Zhang, C. (Author), Zhou, M. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
asymmetric PCR
CRISPR/Cas14a1
nucleic acid detection
spinal muscular atrophy
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