High‐Throughput Profiling of Colorectal Cancer Liver Metastases Reveals Intra‐ and Inter‐Patient Heterogeneity in the EGFR and WNT Pathways Associated with Clinical Outcome

High‐Throughput Profiling of Colorectal Cancer Liver Metastases Reveals Intra‐ and Inter‐Patient Heterogeneity in the EGFR and WNT Pathways Associated with Clinical Outcome

Seventy percent of patients with colorectal cancer develop liver metastases (CRLM), which are a decisive factor in cancer progression. Therapy outcome is largely influenced by tumor heterogeneity, but the intra‐ and inter‐patient heterogeneity of CRLM has been poorly studied. In particular, the cont...

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Bibliographic Details
Main Authors: Beißbarth, T. (Author), Bleckmann, A. (Author), Bohnenberger, H. (Author), Conradi, L.-C (Author), Homayounfar, K. (Author), Korf, U. (Author), Menck, K. (Author), Pukrop, T. (Author), Scheel, A.H (Author), Schildhaus, H.-U (Author), Wachter, A. (Author), Wiemann, S. (Author), Wingender, E. (Author), Wlochowitz, D. (Author), Wolff, A. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
colorectal cancer
EGFR
high-throughput profiling
intratumoral heterogeneity
liver metastasis
WNT
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