High Dose Local Photon Irradiation Is Crucial in Anti-CTLA-4 Antibody Therapy to Enhance the Abscopal Response in a Murine Pancreatic Carcinoma Model

High Dose Local Photon Irradiation Is Crucial in Anti-CTLA-4 Antibody Therapy to Enhance the Abscopal Response in a Murine Pancreatic Carcinoma Model

Pancreatic cancer is an extremely treatment-resistant neoplasm to chemotherapy and immunotherapy. The combination of photon beam irradiation and anti-CTLA-4 antibody (C4) for the anti-tumor effect enhancement at local and distant tumors (abscopal tumors) was investigated using the pancreatic ductal...

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Bibliographic Details
Main Authors: Hayashi, K. (Author), Isohashi, F. (Author), Katsuki, S. (Author), Koizumi, M. (Author), Minami, K. (Author), Ogawa, K. (Author), Seo, Y. (Author), Takahashi, Y. (Author), Takenaka, W. (Author), Tamari, K. (Author), Tatekawa, S. (Author), Yamamoto, J. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
abscopal response
anti-CTLA-4 antibody
cytotoxic T lymphocytes
immune checkpoint inhibitors
pancreatic ductal adenocarcinoma
radiation
regulatory T cell
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