Effectiveness of Naldemedine Compared with Magnesium Oxide in Preventing Opioid-Induced Constipation: A Randomized Controlled Trial

Effectiveness of Naldemedine Compared with Magnesium Oxide in Preventing Opioid-Induced Constipation: A Randomized Controlled Trial

Opioid-induced constipation (OIC) may occur in patients receiving opioid treatment, decreasing their quality of life (QOL). We compared the effectiveness of magnesium oxide (MgO) with that of naldemedine (NAL) in preventing OIC. This proof-of-concept, randomized controlled trial (registration number...

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Main Authors: Fuyuki, A. (Author), Higurashi, T. (Author), Honda, Y. (Author), Ichikawa, Y. (Author), Imajo, K. (Author), Ishiki, H. (Author), Iwaki, M. (Author), Kasai, Y. (Author), Kato, T. (Author), Kessoku, T. (Author), Kobayashi, N. (Author), Kobayashi, T. (Author), Nakajima, A. (Author), Ogawa, Y. (Author), Ozaki, A. (Author), Saito, S. (Author), Suzuki, A. (Author), Taguri, M. (Author), Takahashi, K. (Author), Takeda, Y. (Author), Tanaka, K. (Author), Yamamoto, A. (Author), Yoneda, M. (Author), Yoshihara, T. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
magnesium oxide
naldemedine
opioid-induced constipation
spontaneous bowel movement
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