RB1-Negative Retinal Organoids Display Proliferation of Cone Photoreceptors and Loss of Retinal Differentiation

RB1-Negative Retinal Organoids Display Proliferation of Cone Photoreceptors and Loss of Retinal Differentiation

Retinoblastoma is a tumor of the eye in children under the age of five caused by biallelic inactivation of the RB1 tumor suppressor gene in maturing retinal cells. Cancer models are essential for understanding tumor development and in preclinical research. Because of the complex organization of the...

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Bibliographic Details
Main Authors: Altmüller, J. (Author), Bozet, M. (Author), Brenzel, A. (Author), Döpper, H. (Author), Kanber, D. (Author), Kilpert, F. (Author), Lohmann, D. (Author), Pommerenke, C. (Author), Steenpass, L. (Author), Woestefeld, J. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
retinal organoids
retinoblastoma
RNA-seq
stem cells
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