TRPM8-Rap1A Interaction Sites as Critical Determinants for Adhesion and Migration of Prostate and other Epithelial Cancer Cells

TRPM8-Rap1A Interaction Sites as Critical Determinants for Adhesion and Migration of Prostate and other Epithelial Cancer Cells

Emerging evidence indicates that the TRPM8 channel plays an important role in prostate cancer (PCa) progression, by impairing the motility of these cancer cells. Here, we reveal a novel facet of PCa motility control via direct protein-protein interaction (PPI) of the channel with the small GTPase Ra...

Full description

Bibliographic Details
Main Authors: Audero, M. (Author), Bailleul, Q. (Author), Bernardini, M. (Author), Bokhobza, A. (Author), Brysbaert, G. (Author), Cantelmo, A.R (Author), Chinigò, G. (Author), Cicero, J. (Author), De Ruyck, J. (Author), Gkika, D. (Author), Grolez, G.P (Author), Lensink, M.F (Author), Pla, A.F (Author), Ruffinatti, F.A (Author), Toillon, R.-A (Author), Visentin, L. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
adhesion
calcium channel
GTPase
metastasis
migration
prostate cancer
Rap1A
TRPM8
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items