Reducing Chemotherapy-Induced DNA Damage via nAChR-Mediated Redox Reprograming—A New Mechanism for SCLC Chemoresistance Boosted by Nicotine

Reducing Chemotherapy-Induced DNA Damage via nAChR-Mediated Redox Reprograming—A New Mechanism for SCLC Chemoresistance Boosted by Nicotine

Up to 60% of patients with small cell lung cancer (SCLC) continue to smoke, which is associated with worse clinical outcomes. Platinum-based chemotherapies, in combination with topoisomerase inhibitors, are first-line therapies for SCLC, with rapid chemoresistance as a major barrier. We provided evi...

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Bibliographic Details
Main Authors: Bian, T. (Author), Fujioka, N. (Author), Huo, Z. (Author), Jiang, Y. (Author), Jin, L. (Author), Kaye, F.J (Author), Salloum, R.G (Author), Song, L. (Author), Wang, Y. (Author), Warren, G.W (Author), Xing, C. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
chemoresistance
cotinine
DNA damage
nicotine
platinum-based therapy
SCLC
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