Ephrin B Activate Src Family Kinases in Fibroblasts Inducing Stromal Remodeling in Prostate Cancer

Ephrin B Activate Src Family Kinases in Fibroblasts Inducing Stromal Remodeling in Prostate Cancer

Through stromal-epithelial interactions, carcinoma associated fibroblasts (CAF) play a critical role in tumor growth and progression. Activation of erythrophoyetin-producing human hepatocellular (Eph) receptors has been implicated in cancer. Eph receptor interactions with Ephrin ligands lead to bidi...

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Bibliographic Details
Main Authors: Challasivakanaka, S. (Author), Crawford, S.E (Author), Dufficy, M.F (Author), Filipovich, Y. (Author), Franco, O.E (Author), Gil, V. (Author), Hayward, S.W (Author), Kakarla, M. (Author), Vickman, R. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
carcinoma-associated fibroblasts (CAF)
cytokines
EFNB1
EFNB2
EFNB3
Ephrins
paracrine signaling
prostate cancer
reverse signaling
Src family kinases
stroma
Tenascin-C
tumor microenvironment (TME)
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