Dynamics of Metabolic Pathways and Stress Response Patterns during Human Neural Stem Cell Proliferation and Differentiation

Dynamics of Metabolic Pathways and Stress Response Patterns during Human Neural Stem Cell Proliferation and Differentiation

Understanding early nervous system stress response mechanisms is crucial for studying developmental neurotoxicity and devising neuroprotective treatments. We used hiPSC-derived long-term self-renewing neuroepithelial stem (lt-NES) cells differentiated for up to 12 weeks as an in vitro model of human...

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Bibliographic Details
Main Authors: Bell, C. (Author), Brüstle, O. (Author), Hajo, M. (Author), Haupt, S. (Author), Ingelman-Sundberg, M. (Author), Muthukottiappan, P. (Author), Segschneider, M. (Author), Semkova, V. (Author), Till, A. (Author), Weykopf, B. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
autophagy
neurodevelopment
neuronal differentiation
NRF2
ROS
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