Mutagenic study of benzimidazole derivatives with (+S9) and without (-S9) metabolic activation

Mutagenic study of benzimidazole derivatives with (+S9) and without (-S9) metabolic activation

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Benzimidazole derivatives have a diverse range of biological activities, including antiulcer, antihypertensive, antiviral, antifungal, anti-inflammatory, and anticancer. Despite these activities, previous studies have revealed that some of the derivatives can induce mutations. This study aimed to sc...

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Bibliographic Details
Main Authors: Ab dullah, S.S (Author), Abdullah, R. (Author), Ahmat, N. (Author), Akim, A.M (Author), Azahar, N.H (Author), Hamid, H.A (Author)
Format: Article
Language:English
Published: MDPI AG 2019
Subjects:
2 nitrofluorene
4 (5,6 dimethyl 1h benzo[d]imidazol 2 yl) n' (2 hydro xybenzylidene)benzohydrazide
4 (5,6 dimethyl 1h benzo[d]imidazol 2 yl) n' (3 hydroxybenzylidene)benzohydrazide
Activation, Metabolic
Ames test
animal tissue
antibiotic resistance
Article
bacterial strain
benzimidazole
Benzimidazole
benzimidazole derivative
Benzimidazoles
chemical modification
chemistry
controlled study
drug effect
Drug Resistance, Microbial
drug synthesis
gene
gene deletion
genetic analysis
genetics
genotype
Genotype
liver homogenate
male
metabolic activation
metabolism
mutagenic activity
mutagenic agent
Mutagens
n' (2,4 dihydroxybenzylidene) 4 (5,6 dimethyl 1h benzo[d]imidazol 2 yl)benzohydrazide
n' (2,5 dihydroxybenzylidene) 4 (5,6 dimethyl 1h benzo[d]imidazol 2 yl)benzohydrazide
nonhuman
plasmid
rat
rfa gene
Salmonella enterica serovar Typhimurium
Salmonella typhimurium
scanning electron microscopy
sodium azide
structure activity relation
Structure-Activity Relationship
Structure-activity relationship (SAR)
unclassified drug
uvrb gene
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