Phenotype of Mrps5-Associated Phylogenetic Polymorphisms Is Intimately Linked to Mitoribosomal Misreading

Phenotype of Mrps5-Associated Phylogenetic Polymorphisms Is Intimately Linked to Mitoribosomal Misreading

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We have recently identified point mutation V336Y in mitoribosomal protein Mrps5 (uS5m) as a mitoribosomal ram (ribosomal ambiguity) mutation conferring error-prone mitochondrial protein synthesis. In vivo in transgenic knock-in animals, homologous mutation V338Y was associated with a discrete phenot...

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Bibliographic Details
Main Authors: Akbergenov, R. (Author), Böttger, E.C (Author), Brilkova, M. (Author), Eckert, A. (Author), Fritz, A.-K (Author), Isnard-Petit, P. (Author), Juskeviciene, R. (Author), Laczko, E. (Author), Rehrauer, H. (Author), Schacht, J. (Author), Schmitt, K. (Author), Shcherbakov, D. (Author), Thiam, K. (Author), Wolfer, D.P (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
misreading
mitochondria
mitoribosomal protein
point mutation
protein synthesis
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