Proline Oxidation Supports Mitochondrial ATP Production When Complex I Is Inhibited

Proline Oxidation Supports Mitochondrial ATP Production When Complex I Is Inhibited

The oxidation of proline to pyrroline-5-carboxylate (P5C) leads to the transfer of electrons to ubiquinone in mitochondria that express proline dehydrogenase (ProDH). This electron transfer supports Complexes CIII and CIV, thus generating the protonmotive force. Further catabolism of P5C forms gluta...

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Bibliographic Details
Main Authors: Bui, D. (Author), Chinopoulos, C. (Author), Doerrier, C. (Author), Gnaiger, E. (Author), Komlódi, T. (Author), Nazarian, S. (Author), Pallag, G. (Author), Ravasz, D. (Author), Seyfried, T.N (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
coenzyme Q
proline dehydrogenase
reducing equivalent
substrate-level phosphorylation
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