Genetic Deficiency of Indoleamine 2,3-dioxygenase Aggravates Vascular but Not Liver Disease in a Nonalcoholic Steatohepatitis and Atherosclerosis Comorbidity Model

Genetic Deficiency of Indoleamine 2,3-dioxygenase Aggravates Vascular but Not Liver Disease in a Nonalcoholic Steatohepatitis and Atherosclerosis Comorbidity Model

Nonalcoholic steatohepatitis (NASH) is a chronic liver disease that increases cardiovascular disease risk. Indoleamine 2,3-dioxygenase-1 (IDO1)-mediated tryptophan (Trp) metabolism has been proposed to play an immunomodulatory role in several diseases. The potential of IDO1 to be a link between NASH...

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Bibliographic Details
Main Authors: Abdalla, D.S.P (Author), Arora, A. (Author), Berg, M. (Author), Casagrande, F.B (Author), Cole, J. (Author), Forteza, M.J (Author), Gisterå, A. (Author), Griepke, S. (Author), Kareinen, I. (Author), Ketelhuth, D.F.J (Author), Martins, J.O (Author), Monaco, C. (Author), Tripodi, G.L (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
atherosclerosis
IDO
immunometabolism
inflammation
NASH
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