Characterization of Interactions between CTX-M-15 and Clavulanic Acid, Desfuroylceftiofur, Ceftiofur, Ampicillin, and Nitrocefin

Characterization of Interactions between CTX-M-15 and Clavulanic Acid, Desfuroylceftiofur, Ceftiofur, Ampicillin, and Nitrocefin

Cefotaximase-Munich (CTX-M) extended-spectrum beta-lactamases (ESBLs) are com-monly associated with Gram-negative, hospital-acquired infections worldwide. Several beta-lac-tamase inhibitors, such as clavulanate, are used to inhibit the activity of these enzymes. To under-stand the mechanism of CTX-M...

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Bibliographic Details
Main Authors: Ahmadvand, P. (Author), Avillan, J.J (Author), Call, D.R (Author), Kang, C. (Author), Lewis, J.A (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
antibiotic
antimicrobial resistance
crystal structure
CTX-M-15
inhibition mechanism
inhibitor
β-lactam compounds
β-lactamase
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