Multiomic Profiling Identified EGF Receptor Signaling as a Potential Inhibitor of Type I Interferon Response in Models of Oncolytic Therapy by Vesicular Stomatitis Virus

Multiomic Profiling Identified EGF Receptor Signaling as a Potential Inhibitor of Type I Interferon Response in Models of Oncolytic Therapy by Vesicular Stomatitis Virus

Cancer cell lines responded differentially to type I interferon treatment in models of oncolytic therapy using vesicular stomatitis virus (VSV). Two opposite cases were considered in this study, glioblastoma DBTRG-05MG and osteosarcoma HOS cell lines exhibiting resistance and sensitivity to VSV afte...

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Main Authors: Alekseeva, O.N (Author), Anufrieva, K.S (Author), Arapidi, G.P (Author), Chumakov, P.M (Author), Goncharov, A.O (Author), Gorshkov, M.V (Author), Hamad, A. (Author), Ivanov, M.V (Author), Kliuchnikova, A.A (Author), Kuznetsova, K.G (Author), Lipatova, A.V (Author), Mahmoud, M. (Author), Moshkovskii, S.A (Author), Nikitina, A.S (Author), Pyatnitskiy, M.A (Author), Shakiba, Y. (Author), Tarasova, I.A (Author), Vorobyev, P.O (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
epidermal growth factor receptor
gefitinib
glioblastoma
human epidermal growth factor receptor 2
oncolytic virus
osteosarcoma
type I interferon
vesicular stomatitis virus
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