Plant Alkaloid Tetrandrine Is a Nuclear Receptor 4A1 Antagonist and Inhibits Panc-1 Cell Growth In Vitro and In Vivo

Plant Alkaloid Tetrandrine Is a Nuclear Receptor 4A1 Antagonist and Inhibits Panc-1 Cell Growth In Vitro and In Vivo

The orphan nuclear receptor 4A1 (NR4A1) is highly expressed in human pancreatic cancer cells and exerts pro-oncogenic activity. In a previous study, we demonstrated that fangchinoline (FCN), a natural inhibitor of nuclear NR4A1, induces NR4A1-dependent apoptosis in human pancreatic cancer cells. In...

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Bibliographic Details
Main Authors: Jang, B.I (Author), Kim, D.H (Author), Kim, J.-H (Author), Kim, K.-J (Author), Lee, H.-S (Author), Lee, I.-S (Author), Lee, S.-O (Author), Martin, G. (Author), Park, J.-H (Author), Safe, S. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
antagonist
apoptosis
NR4A1
pancreatic cancer
tetrandrine
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