Smad8 Is Increased in Duchenne Muscular Dystrophy and Suppresses miR-1, miR-133a, and miR-133b

Smad8 Is Increased in Duchenne Muscular Dystrophy and Suppresses miR-1, miR-133a, and miR-133b

Duchenne muscular dystrophy (DMD) is an X-linked recessive disease characterized by skeletal muscle instability, progressive muscle wasting, and fibrosis. A major driver of DMD pathology stems from aberrant upregulation of transforming growth factor β (TGFβ) signaling. In this report, we investigate...

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Bibliographic Details
Main Authors: Alesce, L. (Author), Alexander, M.S (Author), Bamman, M.M (Author), Carlyle, J. (Author), Conklin, M. (Author), Gilbert, S. (Author), Hu, X. (Author), King, P.H (Author), Lopez, M.A (Author), Qushair, F. (Author), Si, Y. (Author), Williams, V. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
BMP4
Duchenne
miRNA
muscle
Smad8
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