Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity

Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity

In addition to involvement in epigenetic gene regulation, histone deacetylases (HDACs) regulate multiple cellular processes through mediating the activity of non-histone protein substrates. The knockdown of HDAC8 isozyme is associated with the inhibition of cell proliferation and apoptosis enhanceme...

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Main Authors: Darwish, S. (Author), Erdmann, F. (Author), Ghazy, E. (Author), Heimburg, T. (Author), Herp, D. (Author), Jung, M. (Author), Oehme, I. (Author), Ridinger, J. (Author), Robaa, D. (Author), Romier, C. (Author), Salem-Altintas, R. (Author), Schmidt, M. (Author), Schmidtkunz, K. (Author), Sippl, W. (Author), Zeyen, P. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
HDAC8
histone deacetylases (HDACs)
neuroblastoma
proteolysis targeting chimera (PROTAC)
synthesis
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