Exercise and Doxorubicin Modify Markers of Iron Overload and Cardiolipin Deficiency in Cardiac Mitochondria

Exercise and Doxorubicin Modify Markers of Iron Overload and Cardiolipin Deficiency in Cardiac Mitochondria

Doxorubicin (DOX) is a chemotherapeutic agent highly effective at limiting cancer progression. Despite the efficacy of this anticancer drug, the clinical use of DOX is limited due to cardiotoxicity. The cardiac mitochondria are implicated as the primary target of DOX, resulting in inactivation of el...

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Bibliographic Details
Main Authors: Boeno, F.P (Author), Bomkamp, M.P (Author), Doerr, V. (Author), Dowllah, I.M (Author), Montalvo, R.N (Author), Moritz, C.E.J (Author), Nguyen, B.L (Author), Smuder, A.J (Author)
Format: Article
Language:English
Published: MDPI 2023
Subjects:
animal
Animals
anthracycline
Antibiotics, Antineoplastic
antineoplastic antibiotic
cardiolipin
Cardiolipins
cardiotoxicity
Cardiotoxicity
doxorubicin
Doxorubicin
female
Female
heart
heart mitochondrion
intermyofibrillar
iron overload
Iron Overload
metabolism
Mitochondria, Heart
oxidative stress
rat
Rats
Rats, Sprague-Dawley
Sprague Dawley rat
subsarcolemmal
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