Acute Downregulation but Not Genetic Ablation of Murine MCU Impairs Suppressive Capacity of Regulatory CD4 T Cells

Acute Downregulation but Not Genetic Ablation of Murine MCU Impairs Suppressive Capacity of Regulatory CD4 T Cells

By virtue of mitochondrial control of energy production, reactive oxygen species (ROS) generation, and maintenance of Ca2+ homeostasis, mitochondria play an essential role in modulating T cell function. The mitochondrial Ca2+ uniporter (MCU) is the pore-forming unit in the main protein complex media...

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Bibliographic Details
Main Authors: Alansary, D. (Author), Boehm, U. (Author), Brand, B. (Author), Jost, P. (Author), Klein, F. (Author), Niemeyer, B.A (Author), Vaeth, M. (Author), Wahl, V. (Author), Wyatt, A. (Author), Yildiz, D. (Author)
Format: Article
Language:English
Published: MDPI 2023
Subjects:
mitochondrial calcium uniporter
regulatory T cells
suppressive capacity
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