Differential Regulation of GPVI-Induced Btk and Syk Activation by PKC, PKA and PP2A in Human Platelets

Differential Regulation of GPVI-Induced Btk and Syk Activation by PKC, PKA and PP2A in Human Platelets

Bruton’s tyrosine kinase (Btk) and spleen tyrosine kinase (Syk) are major signaling proteins in human platelets that are implicated in atherothrombosis and thrombo-inflammation, but the mechanisms controlling their activities are not well understood. Previously, we showed that Syk becomes phosphoryl...

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Bibliographic Details
Main Authors: Heemskerk, J.W.M (Author), Jurk, K. (Author), Kuijpers, M.J.E (Author), Sickmann, A. (Author), Solari, F.A (Author), Walter, U. (Author), Zhang, P. (Author)
Format: Article
Language:English
Published: MDPI 2023
Subjects:
Agammaglobulinaemia Tyrosine Kinase
Blood Platelets
Bruton tyrosine kinase
Bruton’s tyrosine kinase
fibrinogen receptor
human
Humans
metabolism
phospholipase C gamma
Phospholipase C gamma
phosphoprotein phosphatase 2
phosphorylation
Phosphorylation
Platelet Membrane Glycoproteins
platelets
protein kinase C
Protein Kinase C
protein kinase Syk
protein kinases
Protein Phosphatase 2
Syk Kinase
SYK protein, human
thrombocyte
thrombo-inflammation
XLA
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