Effect of Lacking ZKSCAN3 on Autophagy, Lysosomal Biogenesis and Senescence

Effect of Lacking ZKSCAN3 on Autophagy, Lysosomal Biogenesis and Senescence

Transcription factors can affect autophagy activity by promoting or inhibiting the expression of autophagic and lysosomal genes. As a member of the zinc finger family DNA-binding proteins, ZKSCAN3 has been reported to function as a transcriptional repressor of autophagy, silencing of which can induc...

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Bibliographic Details
Main Authors: Feng, Z.-S (Author), Li, D.-Y (Author), Li, S.-M (Author), Li, X.-M (Author), Liang, S. (Author), Liu, H.-F (Author), Sun, L. (Author), Tang, J.-X (Author), Wen, J.-H (Author), Wu, D. (Author), Wu, H.-L (Author), Wu, Y.-S (Author), Yang, C. (Author), Ye, Z.-N (Author)
Format: Article
Language:English
Published: MDPI 2023
Subjects:
animal
Animals
article
attention
autophagy
Autophagy
autophagy (cellular)
biogenesis
cancer cell
cancer growth
controlled study
CRISPR/Cas9
CRISPR-CAS9 system
fluorescence quantitative polymerase chain reaction
gene deletion
gene expression regulation
Gene Expression Regulation
genetic transcription
genetics
HeLa cell line
HeLa Cells
human
human experiment
Humans
knockout gene
lysosomal biogenesis
lysosome
Lysosomes
metabolism
Mice
mouse
protein expression
protein function
quantitative analysis
repressor gene
senescence
transcription factor
Transcription Factors
transcriptome sequencing
tumor-related gene
Western blotting
ZKSCAN3
ZKSCAN3 protein, human
ZKSCAN3 protein, mouse
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