Essential Involvement of Neutrophil Elastase in Acute Acetaminophen Hepatotoxicity Using BALB/c Mice

Essential Involvement of Neutrophil Elastase in Acute Acetaminophen Hepatotoxicity Using BALB/c Mice

Intense neutrophil infiltration into the liver is a characteristic of acetaminophen-induced acute liver injury. Neutrophil elastase is released by neutrophils during inflammation. To elucidate the involvement of neutrophil elastase in acetaminophen-induced liver injury, we investigated the efficacy...

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Bibliographic Details
Main Authors: Harie, I. (Author), Ishida, Y. (Author), Ishigami, A. (Author), Kimura, A. (Author), Kondo, T. (Author), Kuninaka, Y. (Author), Mukaida, N. (Author), Nosaka, M. (Author), Zhang, S. (Author)
Format: Article
Language:English
Published: MDPI 2023
Subjects:
acetaminophen
drug-induced hepatotoxicity
inflammation
mice
neutrophil elastase
neutrophils
sivelestat
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