Synthesis of 1-(2-Hydroxyphenyl)- and (3,5-Dichloro-2-hydroxyphenyl)-5-oxopyrrolidine-3-carboxylic Acid Derivatives as Promising Scaffolds for the Development of Novel Antimicrobial and Anticancer Agents

Synthesis of 1-(2-Hydroxyphenyl)- and (3,5-Dichloro-2-hydroxyphenyl)-5-oxopyrrolidine-3-carboxylic Acid Derivatives as Promising Scaffolds for the Development of Novel Antimicrobial and Anticancer Agents

Increasing antimicrobial resistance among Gram-positive pathogens and pathogenic fungi remains one of the major public healthcare threats. Therefore, novel antimicrobial candidates and scaffolds are critically needed to overcome resistance in Gram-positive pathogens and drug-resistant fungal pathoge...

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Bibliographic Details
Main Authors: Bertašiūtė, M. (Author), Garcia, A. (Author), Grybaitė, B. (Author), Kavaliauskas, P. (Author), Lelešius, R. (Author), Mickevičius, V. (Author), Naing, E. (Author), Petraitienė, R. (Author), Petraitis, V. (Author), Šiugždaitė, J. (Author), Vaickelionienė, R. (Author)
Format: Article
Language:English
Published: MDPI 2023
Subjects:
Anti-Bacterial Agents
anticancer activity
antiinfective agent
Anti-Infective Agents
antimicrobial activity
antineoplastic agent
Antineoplastic Agents
azole
carboxylic acid
Carboxylic Acids
Clostridioides difficile
Fungi
fungus
Gram-positive bacteria
human
Humans
hydrazone
methicillin resistant Staphylococcus aureus
Methicillin-Resistant Staphylococcus aureus
microbial sensitivity test
Microbial Sensitivity Tests
pyrrolidinone
Staphylococcus aureus
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