Multiple Dosing and Preactivation of Mesenchymal Stromal Cells Enhance Efficacy in Established Pneumonia Induced by Antimicrobial-Resistant Klebsiella pneumoniae in Rodents

Multiple Dosing and Preactivation of Mesenchymal Stromal Cells Enhance Efficacy in Established Pneumonia Induced by Antimicrobial-Resistant Klebsiella pneumoniae in Rodents

Antimicrobial-resistant (AMR) bacteria, such as Klebsiella species, are an increasingly common cause of hospital-acquired pneumonia, resulting in high mortality and morbidity. Harnessing the host immune response to AMR bacterial infection using mesenchymal stem cells (MSCs) is a promising approach t...

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Bibliographic Details
Main Authors: Byrnes, D. (Author), Gonzales, H.E (Author), Laffey, J.G (Author), Masterson, C.H (Author), McCarthy, S.D (Author), O’Toole, D.P (Author)
Format: Article
Language:English
Published: MDPI 2023
Subjects:
inflammation
mesenchymal stem cells
multiple doses
pneumonia
preactivation
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