The Prohibitin-Binding Compound Fluorizoline Activates the Integrated Stress Response through the eIF2α Kinase HRI

The Prohibitin-Binding Compound Fluorizoline Activates the Integrated Stress Response through the eIF2α Kinase HRI

Fluorizoline is a synthetic molecule that induces apoptosis, by selectively targeting prohibitins (PHBs), through induction of the BH3-only protein NOXA. This induction is transcriptionally regulated by the integrated stress response (ISR)-related transcription factors ATF3 and ATF4. Here, we evalua...

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Bibliographic Details
Main Authors: Cosialls, A.M (Author), Ghashghaei, O. (Author), Gil, J. (Author), Heib, J. (Author), Iglesias-Serret, D. (Author), Lavilla, R. (Author), Nadal Rodríguez, P. (Author), Núñez-Vázquez, S. (Author), Pons, G. (Author), Sánchez-Vera, I. (Author), Saura-Esteller, J. (Author)
Format: Article
Language:English
Published: MDPI 2023
Subjects:
activating transcription factor 4
Activating Transcription Factor 4
apoptosis
Apoptosis
eIF-2 Kinase
endoplasmic reticulum stress
Endoplasmic Reticulum Stress
ER-stress
Eukaryotic Initiation Factor-2
fluorizoline
genetics
HeLa cell line
HeLa Cells
HRI
human
Humans
initiation factor 2
ISR
metabolism
mitochondrial-stress
prohibitin
Prohibitins
protein kinase R
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