DNA Methylation by Bisulfite Next-Generation Sequencing for MLH1 and MGMT in Oral Squamous Cell Carcinomas and Potentially Malignant Disorders: An Integrative Analysis towards Field Cancerization

DNA Methylation by Bisulfite Next-Generation Sequencing for MLH1 and MGMT in Oral Squamous Cell Carcinomas and Potentially Malignant Disorders: An Integrative Analysis towards Field Cancerization

Background and Objectives: MGMT methylation is a well-described biomarker in several solid tumors and MLH1 seems to occur in the initial stages of oral carcinogenesis. The aims of this study were to evaluate MHL1 and MGMT methylation levels in oral squamous cell carcinoma (OSCC) and oral potentially...

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Bibliographic Details
Main Authors: Blanco-Carrión, A. (Author), Chamorro-Petronacci, C.M (Author), Gándara-Vila, P. (Author), Lorenzo-Pouso, A.I (Author), Padin-Iruegas, E. (Author), Pérez-Jardón, A. (Author), Pérez-Sayans, M. (Author), Sines-Cajade, I. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
DNA methylation
MGMT
MLH1
next-generation sequencing
oral squamous cell carcinoma
potentially malignant disorders
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