Phenoxyacetohydrazide schiff bases: β-glucuronidase inhibitors

Phenoxyacetohydrazide schiff bases: β-glucuronidase inhibitors

Phenoxyacetohydrazide Schiff base analogs 1-28 have been synthesized and their in vitro β-glucouoronidase inhibition potential studied. Compounds 1 (IC50 = 9.20 ± 0.32 μM), 5 (IC50= 9.47 ± 0.16 μM), 7 (IC50 = 14.7 ± 0.19 μM), 8 (IC50 = 15.4 ± 1.56 μM), 11 (IC50 = 19.6 ± 0.62 μM), 12 (IC50 = 30.7 ± 1...

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Bibliographic Details
Main Authors: Ambreen, N. (Author), Choudhary, M.I (Author), Ismail, N.H (Author), Jamil, W. (Author), Khan, K.M (Author), Perveen, S. (Author), Shah, S.A.A (Author), Taha, M. (Author)
Format: Article
Language:English
Published: MDPI AG 2014
Subjects:
animal
Animals
antagonists and inhibitors
beta glucuronidase
Bovinae
bovine
Cattle
chemistry
D-saccharic acid-1 4-lactone
enzyme inhibitor
Enzyme Inhibitors
Glucuronidase
Glucuronosyl-O-bonds
hydrazine derivative
Hydrazines
Phenoxyacetates
phenoxyacetic acid derivative
Phenoxyacetohydrazide
Schiff base
Schiff bases
Schiff Bases
β-glucouoronidase
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