Design, synthesis and docking studies of flavokawain B type chalcones and their cytotoxic effects on MCF-7 and MDA-MB-231 cell lines

Design, synthesis and docking studies of flavokawain B type chalcones and their cytotoxic effects on MCF-7 and MDA-MB-231 cell lines

Flavokawain B (1) is a natural chalcone extracted from the roots of Piper methysticum, and has been proven to be a potential cytotoxic compound. Using the partial structure of flavokawain B (FKB), about 23 analogs have been synthesized. Among them, compounds 8, 13 and 23 were found in new FKB deriva...

Full description

Bibliographic Details
Main Authors: Akhtar, M.N (Author), Ali, N.M (Author), Alitheen, N.B (Author), Bakar, A.A (Author), Loh, W.-S (Author), Quah, C.K (Author), Shah, S.A.A (Author), Ul-Haq, Z. (Author), Yeap, S.K (Author), Zareen, S. (Author)
Format: Article
Language:English
Published: MDPI AG 2018
Subjects:
Anti-cancer
antineoplastic agent
Antineoplastic Agents, Phytogenic
binding site
Binding Sites
Breast cancer cell lines
Catalytic Domain
cell proliferation
Cell Proliferation
cell survival
Cell Survival
chalcone derivative
Chalcone synthesis
Chalcones
chemical structure
chemistry
Chemistry Techniques, Synthetic
drug design
Drug Design
drug effect
drug screening
Drug Screening Assays, Antitumor
enzyme active site
flavokawain B
Flavokawain B derivatives
flavonoid
Flavonoids
human
Humans
Magnetic Resonance Spectroscopy
MCF-7 cell line
MCF-7 Cells
molecular docking
Molecular Docking Simulation
Molecular Structure
nuclear magnetic resonance spectroscopy
protein binding
Protein Binding
SARs
structure activity relation
Structure-Activity Relationship
synthesis
Online Access:View Fulltext in Publisher
View in Scopus

Internet

View Fulltext in Publisher
View in Scopus

Similar Items