Central composite design for formulation and optimization of solid lipid nanoparticles to enhance oral bioavailability of acyclovir

Central composite design for formulation and optimization of solid lipid nanoparticles to enhance oral bioavailability of acyclovir

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Treatment of herpes simplex infection requires high and frequent doses of oral acyclovir to attain its maximum therapeutic effect. The current therapeutic regimen of acyclovir is known to cause unwarranted dose-related adverse effects, including acute kidney injury. For this reason, a suitable deliv...

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Bibliographic Details
Main Authors: Adam, S.K (Author), Affandi, M.M.R.M.M (Author), Alias, E. (Author), Basir, R. (Author), Hassan, H. (Author), Shamsuddin, A.F (Author)
Format: Article
Language:English
Published: MDPI 2021
Series:Molecules
Subjects:
aciclovir
Acyclovir
animal
Animals
bioavailability
Bioavailability
Biological Availability
Central composite design
chemistry
drug carrier
Drug Carriers
lipid
Lipids
nanoparticle
Nanoparticles
Oral delivery
particle size
Particle Size
rat
Rats
Solid lipid nanoparticles
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