Synthesis, Characterization, and In Vivo Study of Some Novel 3,4,5-Trimethoxybenzylidene-hydrazinecarbothioamides and Thiadiazoles as Anti-Apoptotic Caspase-3 Inhibitors

Synthesis, Characterization, and In Vivo Study of Some Novel 3,4,5-Trimethoxybenzylidene-hydrazinecarbothioamides and Thiadiazoles as Anti-Apoptotic Caspase-3 Inhibitors

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The present study aims to discover novel derivatives as antiapoptotic agents and their protective effects against renal ischemia/reperfusion. Therefore, a series of new thiadiazole analogues 2a–g was designed and synthesized through cyclization of the corresponding opened hydrazinecarbothioamides 1a...

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Bibliographic Details
Main Authors: Abdelhafez, E.-S.M.N (Author), Abdelhafez, S.M.N (Author), Abdelzaher, W.Y (Author), Aly, A.A (Author), Bräse, S. (Author), Mostafa, S.M (Author), Nieger, M. (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
animal
Animals
antiapoptotic activity
apoptosis
Apoptosis
caspase 3
Caspase 3
caspase-3
chemistry
cytochrome c
Cytochromes c
histochemical staining
hydrazinecarbothioamides
metabolism
molecular docking
Molecular Docking Simulation
rat
Rats
selectivity
structure activity relation
Structure-Activity Relationship
thiadiazole derivative
thiadiazoles
Thiadiazoles
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