Bioactivities and Mode of Actions of Dibutyl Phthalates and Nocardamine from Streptomyces sp. H11809

Bioactivities and Mode of Actions of Dibutyl Phthalates and Nocardamine from Streptomyces sp. H11809

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Dibutyl phthalate (DBP) produced by Streptomyces sp. H11809 exerted inhibitory activity against human GSK-3β (Hs GSK-3β) and Plasmodium falciparum 3D7 (Pf 3D7) malaria parasites. The current study aimed to determine DBP’s plausible mode of action against Hs GSK-3β and Pf 3D7. Molecular docking analy...

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Bibliographic Details
Main Authors: Embi, N. (Author), Gansau, J.A (Author), How, S.E (Author), Lai, N.S (Author), Lee, P.-C (Author), Leow, C.H (Author), Mahmud, F. (Author), Mustaffa, K.M.F (Author), Osman, H. (Author), Sidek, H.M (Author)
Format: Article
Language:English
Published: MDPI 2022
Subjects:
antimalarial
antimalarial agent
Antimalarials
cyclopeptide
deferrioxamine E
dibutyl phthalate
Dibutyl Phthalate
Glycogen Synthase Kinase 3 beta
glycogen synthase kinase 3beta
GSK-3β inhibitors
human
Humans
iron-chelating
mixed inhibition
molecular docking
Molecular Docking Simulation
nocardamine
Peptides, Cyclic
phthalic acid dibutyl ester
Streptomyces
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