Significant decreased expressions of CaN, VEGF, SLC39A6 and SFRP1 in MDA-MB-231 xenograft breast tumor mice treated with moringa oleifera leaves and seed residue (MOLSr) extracts

Moringa oleifera is a miracle plant with many nutritional and medicinal properties. Chemopreventive values of the combined mixture of moringa leaves and seed residue (MOLSr) at different ratios (M1S9, M1S1 and M9S1) were investigated. MOLSr extracts were subjected to phytochemical screening, antioxi...

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Bibliographic Details
Main Authors:	Lim, W.F (Author), Salleh, M.Z (Author), Teh, L.K (Author), Yusof, M.I.M (Author)
Format:	Article
Language:	English
Published:	MDPI AG, 2020
Subjects:	amino acid derivative angiogenesis animal animal cell animal experiment animal model Animals antineoplastic activity antineoplastic agent Antineoplastic Agents antioxidant antioxidant activity Antioxidants Article ascorbic acid astragalin benzoic acid body weight change breast cancer breast epithelium cell Breast Neoplasms breast tumor calcineurin Calcineurin cancer growth cancer inhibition cancer model cation transport protein Cation Transport Proteins cell cycle Cell Line, Tumor cell structure cell survival Cell Survival cell viability chemistry Chemoprevention chemoprophylaxis connective tissue controlled study down regulation DPPH radical scavenging assay drug cytotoxicity drug effect drug megadose epithelial mesenchymal transition experimental mammary neoplasm female Female ferric reducing antioxidant power assay gene expression Gene expression profiling glucosinalbin glucosinolate glucotropaeolin HCT 116 cell line HeLa cell line Hep-G2 cell line heptadecane Heterografts human human cell IC50 isoquercetin isorhamnetin kaempferol low drug dose Mammary Neoplasms, Experimental MCF-7 MCF-7 cell line MDA-MB-231 MDA-MB-231 cell line membrane protein Membrane Proteins metabolic fingerprinting metabolism Mice Moringa leaves and seed residue Moringa oleifera Moringa oleifera extract mouse niazirin nonhuman palmitic acid para coumaric acid phenol derivative plant extract Plant Extracts plant leaf Plant Leaves plant medicinal product plant seed quercetin quinoline saponin derivative secreted frizzled related protein 1 Seeds Sfrp1 protein, mouse signal transduction Slc39a6 protein, mouse solute carrier family 39 member 6 solute carrier protein strophanthidin tamoxifen tannin derivative trolox C tumor cell line tumor volume tumor xenograft unclassified drug vanillin Vascular Endothelial Growth Factors vasculotropin xenograft
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Significant decreased expressions of CaN, VEGF, SLC39A6 and SFRP1 in MDA-MB-231 xenograft breast tumor mice treated with moringa oleifera leaves and seed residue (MOLSr) extracts

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