Dual anti-malarial and gsk3β-mediated cytokine-modulating activities of quercetin are requisite of its potential as a plant-derived therapeutic in malaria

Dual anti-malarial and gsk3β-mediated cytokine-modulating activities of quercetin are requisite of its potential as a plant-derived therapeutic in malaria

Although death in malaria is attributed to cerebrovascular blockage and anaemia, over-whelming cytokine production can contribute to the severity of the disease. Therefore, mitigation of dysregulated inflammatory signalling may provide further benefit for malaria treatment. Quercetin (3,3′,4′,5,7-pe...

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Bibliographic Details
Main Authors: Agustar, H.K (Author), Ali, A.H (Author), Basir, R. (Author), Embi, N. (Author), Hassan, W.R.M (Author), Latip, J. (Author), Shi-Jing, N. (Author), Sidek, H.M (Author), Sudi, S. (Author)
Format: Article
Language:English
Published: MDPI AG 2021
Series:Pharmaceuticals
Subjects:
animal experiment
animal model
animal tissue
antiinflammatory activity
antimalarial activity
Article
behavior change
cerebral malaria
chloroquine
controlled study
Cytokine
cytotoxicity
drug selectivity
enzyme inhibition
enzyme phosphorylation
gamma interferon
glycogen synthase kinase 3beta
GSK3β
IC50
immunoreactivity
in vitro study
in vivo study
interleukin 10
interleukin 4
lactate dehydrogenase
Malaria
male
median survival time
mouse
nonhuman
Plasmodium berghei
Plasmodium falciparum
protein blood level
quercetin
Quercetin
survival rate
tumor necrosis factor
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