Synthesis, molecular docking, and antimalarial activity of hybrid 4-aminoquinoline-pyrano[2,3-c]pyrazole derivatives

Synthesis, molecular docking, and antimalarial activity of hybrid 4-aminoquinoline-pyrano[2,3-c]pyrazole derivatives

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Widespread resistance of Plasmodium falciparum to current artemisinin-based combination therapies necessitate the discovery of new medicines. Pharmacophoric hybridization has become an alternative for drug resistance that lowers the risk of drug–drug adverse interactions. In this study, we synthesiz...

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Bibliographic Details
Main Authors: Abd Razak, M.R.M (Author), Agustar, H.K (Author), Ali, A.H (Author), Hamzah, A.S (Author), Hassan, N.I (Author), Lam, K.W (Author), Latip, J. (Author), Mark-Lee, W.F (Author), Mohammat, M.F (Author), Shaameri, Z. (Author), Shamsuddin, M.A (Author), Zakaria, N.H (Author)
Format: Article
Language:English
Published: MDPI 2021
Series:Pharmaceuticals
Subjects:
4-aminoquinoline
Antimalarial
Docking
Hybrid
Pyrano[2,3-c]pyrazole
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